DIAGNOSE VON KREBS, DESSEN ZELLEN DAS AM TYROSIN PHOSPHORYLIERTE CRKL-PROTEIN EXPRIMIEREN
摘要
The invention relates to methods and kits for diagnosing cancers arising from cells which express tyrosine phosphorylated CRKL protein, such as cells having the Philadelphia (Ph) chromosome, which includes chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL), through the detection of increased levels of phosphorylated CRKL protein or through the detection of increased CRKL gene copy or mRNA expression. The invention also relates to methods of treating such cancers.
申请公布号
DE69507470(D1)
申请公布日期
1999.03.04
申请号
DE1995607470
申请日期
1995.05.12
申请人
CHILDREN'S HOSPITAL OF LOS ANGELES, LOS ANGELES, CALIF., US
发明人
GROFFEN, JOHN H., LOS ANGELES, CA 90027, US;HEISTERKAMP, NORA C., LOS ANGELES, CA 90027, US;TEN HOEVE, JOHANNA, LOS ANGELES, CA 90039, US
