OXAZOLIDINONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS

摘要

The invention concerns a compound of formula (I) wherein, for example R<1> is of the formula -NHC(=O)R<a> wherein R<a> is hydrogen, or (1-4C)alkyl; R<2> and R<3> are independently hydrogen or fluoro; R<4> is hydrogen, (1-4C)alkyl, halo or trifluoromethyl; R<5> and R<6> are, for example, independently hydrogen, (1-4C)alkyl, an acetylene of the formula --H or --(1-4C)alkyl, or a group of formula (IA) wherein, for example, Z is hydrogen or (1-4C)alkyl; X and Y are (1-4C)alkyl, halo, cyano, phenyl or heteroaryl; provided that X, Y and Z do not define a (2-4C)alkenyl group and provided that at least one of R<5> and R<6> is a group of formula (IA) or an acetylene of the formula --H or --(1-4C)alkyl; and pharmaceutically acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.