| 摘要 |
The present invention relates to a bioactive conjugate adapted to coat a metal implant outer surface, which has the following structural formula I:-R-X-PIwherein, R is O or S, adapted to be covalently attached to an implant surface; X is selected from a bond, linear or branched chains of 1 to 30 covalently attached atoms of at least C, N, O Si or S, rings of 1 to 20 covalently attached atoms of at least C, N, O Si or S, and a combination thereof; and P is a bioactive molecule moiety which promotes tissue growth, stabilization and integration, and wherein said moiety retains its biological activity.
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