| 摘要 |
PROBLEM TO BE SOLVED: To obtain a TNF production inhibitor efficiently suppressing TNF production, having antitumor activity and useful for treatment of e.g. cancer, rheumatoid arthritis by including a specific morphine derivative (acid-added salt) as an active ingredient. SOLUTION: This inhibitor comprises a morphine derivative or its pharmacologically acceptable acid-added salt thereof expressed by the formula (R is a lower alkanoyl) as an active ingredient, such as 3-acetoxy-6β- acetylthio-10-oxo-N-cyclopropylmethyl-dihydronormorphine. The daily dose of the morphine derivative (acid-added salt) of the formula is preferably 0.02-10 mg/kg body weight per adult.
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