| 摘要 |
PROBLEM TO BE SOLVED: To obtain the new subject substance useful as an antiasthmatic agent, a bronchodilator, a therapeutic agent for bronchitis, obtainable from a strain belonging to the genus Streptomyces, having inhibitory actions on phosphodiesterase. SOLUTION: This new substance is a physiologically active substance NA00226B showing the following physical and chemical properties or its pharmaceutically acceptable salt. Appearance: red powder. Molecular weight: 447. Molecular formula: C23 H29 NO8 . Solubility: soluble in a lower alcohol and insoluble in hexane, petroleum ether and water. Rf value by ODS thin film chromatography: 0.42 by a developing solvent of acetonitrile-water-formic acid (50:50:1 v/v). Color reaction: positive in vanillin-sulfuric acid, iron chloride and iodine, etc. The physiologically active substance is obtained by culturing a bacterium belonging to the genus Streptomyces capable of producing a physiologically active NA00226B in a medium, forming and accumulating the substance in the culture product and collecting the substance. |
