发明名称 |
Yeast cells engineered to produce pheromone system protein surrogates and uses therefor |
摘要 |
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of alpha -factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
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申请公布号 |
US5876951(A) |
申请公布日期 |
1999.03.02 |
申请号 |
US19950461598 |
申请日期 |
1995.06.05 |
申请人 |
CADUS PHARMACEUTICAL CORPORATION |
发明人 |
FOWLKES, DANA M.;BROACH, JIM;MANFREDI, JOHN;KLEIN, CHRISTINE;MURPHY, ANDREW J.;PAUL, JEREMY;TRUEHEART, JOSHUA |
分类号 |
C07K14/395;C12N15/81;(IPC1-7):G01N33/53 |
主分类号 |
C07K14/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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