| 摘要 |
PROBLEM TO BE SOLVED: To provide the subject new polynucleotide having high identity with a nucleic acid sequence coding for HFIAO41 polypeptide having a specific amino acid sequence and useful for the treatment, diagnosis, etc., of infectious diseases, cancer, diabetes, asthma, hypertension, myocardial infarction, nervous disturbance, etc. SOLUTION: The objective polynucleotide is an isolated new polynucleotide containing a nucleotide sequence having an identity of >=80% with the whole length of a nucleotide sequence coding for HFIAO41 polypeptide of the formula and coding for a polypeptide having the activity of HFIAO41 polypeptide or a nucleotide sequence complementary to the above nucleotide sequence. HFIAO 41 polypeptide and the polynucleotide are useful for the treatment, etc., of infectious diseases, pain, cancer, diabetes, obesity, dysorexia, hyperphagia, asthma, Parkinson's disease, acute cardiac insufficiency, hypotension, hypertension, urinary stasis, osteoporosis, stenocardia, myocardial infarction, ulcer, allergy, benign prostatic hyperplasia, etc. The polynucleotide can be obtained from a natural source such as human placenta genom DNA library. |
