| 发明名称 |
Thrombin inhibitor from the saliva of protostomia |
| 摘要 |
PCT No. PCT/DE93/01172 Sec. 371 Date Aug. 24, 1995 Sec. 102(e) Date Aug. 24, 1995 PCT Filed Dec. 3, 1993 PCT Pub. No. WO94/13807 PCT Pub. Date Jun. 23, 1994The invention relates to a natural protein or a protein that can be synthetically produced, which is a thrombin inhibitor and can be isolated from the saliva of insects which suck the blood of mammals. Preferred is the Triatoma pallidipennis insect. The protein is used for the treatment of thromboses or unstable angina or arteriosclerosis, or for the prevention of a reblockage of vessels after PTCA/PTA or for the prevention of blood clotting in hemodialysis.
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| 申请公布号 |
US5876971(A) |
申请公布日期 |
1999.03.02 |
| 申请号 |
US19950448438 |
申请日期 |
1995.08.24 |
| 申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
NOESKE-JUNGBLUT, CHRISTIANE;SCHLEUNING, WOLF-DIETER;ALAGON, ALEJANDRO;POSSANI, LOURIVAL;CUEVAS-AGUIERRE, DELIA;DONNER, PETER;HAENDLER, BERNARD;HECHLER, ULRIKE |
| 分类号 |
C12N15/09;A61K35/12;A61K35/56;A61K35/64;A61K38/00;A61K38/55;A61K38/57;A61P7/02;A61P9/10;C07H21/04;C07K1/14;C07K14/435;C07K14/81;C12N1/21;C12N5/10;C12N9/99;C12N15/15;C12P21/00;C12P21/02;(IPC1-7):C12P21/02;C07K1/36;A61K38/16 |
主分类号 |
C12N15/09 |
| 代理机构 |
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