发明名称 |
Mice mutant for functional Fc receptors and method of treating autoimmune diseases |
摘要 |
Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a domain of a human Fc receptor, as well as DNA encoding such Fc receptor-based proteins. Also disclosed are in vivo methods for identifying proinflammatory agents that depend on a functional Fc receptor, in vivo methods for identifying proinflammatory agents that do not depend on a functional Fc receptor, and both in vivo and in vitro methods of identifying anti-inflammatory agents. Pharmaceutical compositions containing, and methods of treating inflammation with anti-inflammatory agents are also described.
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申请公布号 |
US5877396(A) |
申请公布日期 |
1999.03.02 |
申请号 |
US19940292569 |
申请日期 |
1994.08.18 |
申请人 |
SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
RAVETCH, JEFFREY V.;TAKAI, TOSHIYUKI;SYLVESTRE, DIANA;CLYNES, RAPHAEL |
分类号 |
C07K14/735;C12N15/85;(IPC1-7):A61K49/00;C12N15/00;G01N31/00 |
主分类号 |
C07K14/735 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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