发明名称 |
Live recombinant vaccine comprising inefficiently or non-replicating virus |
摘要 |
The subject invention pertains to a novel recombinant vaccinia virus vaccine for use in immunizing animals and humans against disease. The vaccine comprises a live vaccinia or replication deficient mutant vaccinia virus capable of expressing a single or multiple heterologous genes or gene fragments. In a preferred embodiment, the recombinant virus is contained in an orally-administered package that will only dissolve in the host animal's gut. The subject invention also pertains to a method of inducing a broad protective immune response through the oral, intranasal, or other mucosal means of administration of the recombinant vaccinia virus vaccine. |
申请公布号 |
AU3910097(A) |
申请公布日期 |
1999.03.01 |
申请号 |
AU19970039100 |
申请日期 |
1997.08.05 |
申请人 |
UNIVERSITY OF FLORIDA;THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY |
发明人 |
PARKER A. SMALL JR.;BRADLEY STEPHEN BENDER;CATHERINE ANN MEITIN;BERNARD MOSS |
分类号 |
A61K39/145;C07K14/11;C12N7/04 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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