发明名称 |
PROCESSO DE PREPARACAO DE PROTEASE DE INTERLEUCINA 1B,DE INIBIDORES DA PROTEASE DE INTERLEUCINA 1B E DE COMPOSICOES FARMACEUTICAS |
摘要 |
<p>There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1 beta and for a substrate comprising : R1-Asp-R2-R3 wherein R1 and R3 are independently any D or L isomer amino acid, R2 is Ala or Gly, and wherein the specific protease cleavage site is between Asp and R2. Inhibitor compounds, compositions and methods for inhibiting Interleukin 1 beta protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp.</p> |
申请公布号 |
PT99118(B) |
申请公布日期 |
1999.02.26 |
申请号 |
PT19910099118 |
申请日期 |
1991.09.30 |
申请人 |
SANOFI |
发明人 |
ROY A. BLACK;PAUL R. SLEATH;SHIRLEY R. KRONHEIM |
分类号 |
C07K14/81;A61K38/00;A61K38/04;A61K38/46;A61K38/55;A61P3/02;A61P17/00;A61P17/02;A61P19/02;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C07C271/22;C07H21/04;C07K5/02;C07K5/06;C07K5/065;C07K5/078;C07K5/08;C07K5/10;C07K5/117;C07K7/06;C07K14/47;C07K14/545;C12N9/50;C12N9/52;C12N9/64;C12N9/99;C12N15/09;C12N15/24;C12N15/25;C12N15/57;C12P21/02;C12R1/91;(IPC1-7):C12N15/57;C07K5/04;A61K38/54 |
主分类号 |
C07K14/81 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|