发明名称 |
STIMULATION, MODULATION AND/OR INHIBITION OF ENDOTHELIAL PROTEOLYTIC ACTIVITY AND/OR ANGIOGENIC ACTIVITY |
摘要 |
Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factor-C (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic in vitro especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2-antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion.
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申请公布号 |
CA2300964(A1) |
申请公布日期 |
1999.02.25 |
申请号 |
CA19982300964 |
申请日期 |
1998.08.14 |
申请人 |
UNIVERSITY OF GENEVA;LUDWIG INSTITUTE FOR CANCER RESEARCH;HELSINKI UNIVERSITY LICENSING LTD. OY |
发明人 |
ERIKSSON, ULF;ALITALO, KARI;PEPPER, MICHAEL S. |
分类号 |
C12N15/09;A61K38/00;A61K38/19;A61K38/57;C07K14/50;C07K14/52;C07K14/81;C07K16/22;C07K16/24;C12N5/06;C12N15/12;C12Q1/68;(IPC1-7):A01N37/18;C12N5/00;C07H21/04;A01N43/04;C12N5/10 |
主分类号 |
C12N15/09 |
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