发明名称 |
NON-MYELOABLATIVE TOLEROGENIC TREATMENT |
摘要 |
The present invention features a method of inducing donor-specific tolerance in a host. Tolerogenic treatments of the present invention may be administered to a host prior to transplantation of donor-derived materials. The tolerogenic treatment involves (1) administering an immunosuppressive agent to a host mammal in a non-myeloablative regimen sufficient to decrease, but not necessarily to eliminate, the host mammal's functional T lymphocyte population; (2) infusing donor antigens from a non-syngeneic donor into the host mammal; (3) eliminating those host T lymphocytes responding to the infused donor antigens using a non-myeloablative dose of lymphocytotoxic or tolerizing agent; and (4) administering donor hematopoietic cells to the host mammal. |
申请公布号 |
WO9852582(A3) |
申请公布日期 |
1999.02.25 |
申请号 |
WO1998US10575 |
申请日期 |
1998.05.22 |
申请人 |
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.;BAXTER INTERNATIONAL INC.;SLAVIN, SHIMON;PRIGOZHINA, TATYANA |
发明人 |
SLAVIN, SHIMON;PRIGOZHINA, TATYANA |
分类号 |
A01K67/027;A61K35/12;A61K35/18;A61K35/28;A61K39/00;A61K45/00;A61P37/06;C12N5/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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