摘要 |
Disclosed are methods and compositions for identifying compounds having an ability to modulate expression of a morphogen, particularly OP-1, OP-1 homologues and closely related proteins, using one or more OP-1-specific, non-coding sequences and a suitable reporter gene. In preferred embodiments, the OP-1-specific non-coding DNA sequence comprises a Pax-responsive OP-1-modulating element. |
申请人 |
CREATIVE BIOMOLECULES, INC.;DORAI, HAIMANTI;SHEPARD, ALYSSA, A.;SAMPATH, KUBER, T.;OPPERMANN, HERMAN |
发明人 |
DORAI, HAIMANTI;SHEPARD, ALYSSA, A.;SAMPATH, KUBER, T.;OPPERMANN, HERMAN |