CELL CHEMOTACTIC FACTOR (CCTF) ORIGINATING IN MAMMALIAN TOOTH PRECEMENT OR CEMENT, METHOD FOR PURIFYING THE SAME, AND NOVEL CONNECTIVE TISSUE ADHESION PROMOTERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

A cell chemotactic factor (CCTF) originating in mammalian tooth precement or cement which has a molecular weight of 67,000 ~ 1,000 determined by SDS-PAGE. A method which comprises taking up the precement or cement from extracted mammalian teeth, immersing the same in physiological saline optionally containing collagenase, and purifying the above CCTF from the resultant eluate by molecular weight fractionation, ion exchange adsorption chromatography and hydroxy-apatite adsorption chromatography.