发明名称 Naphthyl compounds intermediates compositions and methods of use
摘要 The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use. The novel naphthyl compounds have the formula <CHEM> wherein R<1> is -H, -OH, -O(C1-C4 alkyl), -OCOAr where Ar is phenyl or substituted phenyl, -O(CO)OAr where Ar is phenyl or substituted phenyl, -OCO(C1-C6 alkyl), -O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R<2> is -H, -F, -Cl, -OH, -O(C1-C4 alkyl), -OCOAr where Ar is phenyl or substituted phenyl, -O(CO)OAr where Ar is phenyl or substituted phenyl, -OCO(C1-C6 alkyl), -O(CO)O(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R<3> and R<4> are, independently, -H, -F, -Cl, -CH3, -OH,-O(C1-C4 alkyl), -OCOAr where Ar is phenyl or substituted phenyl, -OCO(C1-C6 alkyl), -O(CO)O(C1-C6 alkyl), or-OSO2(C4-C6 alkyl), with the proviso that both R<3> and R<4> cannot be hydrogen; n is 2 or 3; and R<5> is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof.
申请公布号 ZA9707619(B) 申请公布日期 1999.02.25
申请号 ZA19970007619 申请日期 1997.08.25
申请人 ELI LILLY AND COMPANY 发明人 HENRY UHLMAN BRYANT;CHARLES DAVID JONES;THOMAS ALAN CROWELL;ALAN DAVID PALKOWITZ
分类号 C07D295/08;A61K31/138;A61K31/215;A61K31/225;A61K31/4453;A61P3/06;A61P5/30;A61P19/08;C07C41/26;C07C41/28;C07C43/23;C07C43/295;C07C45/46;C07C45/71;C07C47/546;C07C47/575;C07C49/753;C07C49/755;C07C51/367;C07C59/64;C07C67/03;C07C67/317;C07C69/017;C07C69/157;C07D295/092 主分类号 C07D295/08
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