发明名称 VACCINATION BY TOPICAL APPLICATION OF GENETIC VECTORS
摘要 The present invention provides a method of inducing an immune response in a non-invasive mode, comprising the step of: contacting skin of an individual in need of such treatment topically by applying to said skin an immunologically effective concentration of a genetic vector encoding a gene of interest. Also provided is a method of inducing an anti-tumor immune response in an animal in need of such treatment, comprising the step of: contacting skin of said animal topically by applying to said skin an immunologically effective concentration of a vector encoding a gene which encodes an antigen which induces an anti-tumor effect in said animal following administration. The genetic vector may include adenovirus recombinants, DNA/adenovirus complexes, DNA/liposome complexes, or any other vectors capable of expressing transgenes. Topical application of genetic vectors may preferably include a device as designed therein.
申请公布号 WO9908713(A1) 申请公布日期 1999.02.25
申请号 WO1998US16739 申请日期 1998.08.13
申请人 THE UAB RESEARCH FOUNDATION;TANG, DE-CHU;MARKS, DONALD, H.;CURIEL, DAVID, T.;SHI, ZHONGKAI 发明人 TANG, DE-CHU;MARKS, DONALD, H.;CURIEL, DAVID, T.;SHI, ZHONGKAI
分类号 C12N15/09;A61K48/00;A61P37/04;C12N5/10;(IPC1-7):A61K48/00;C12N15/63 主分类号 C12N15/09
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