HYPOXIA-REGULATED GENES

摘要

According to the present invention polynucleotide sequences as set forth in SEQ ID No:1, SEQ ID No:2, SED ID No:3, SEQ ID No:4, SEQ ID No:5, SED ID No:6, SEQ ID No:7, SEQ ID No:8, SEQ ID No:9, SEQ ID No:10 and SEQ ID No:11 are disclosed which are hypoxia regu lated. The present invention provides methods of regulating angiogenesis or apoptosis or regulating response to hypoxic conditions in a patient in need of such treatment. The present invention also provides a method of diagnosing the presence of ischemia in a patient including the steps of analyzing a bodily fluid or tissue sample from the patient for the presence or gene product of at least one expressed gene (up-regulated) as identified by the sequences of SEQ ID No:1, SEQ ID No:2, SEQ ID No:3, SEQ ID No:4, SEQ ID No:5, SEQ ID No:6, SEQ ID No:7, SEQ ID No:8, SEQ ID No:9, SEQ ID No:10 and SEQ No:11 and where ischemia is determined if the up-regulated gene or gene product is ascertained.