发明名称 |
Secretion of human protein linked to gamma interferon signal peptide |
摘要 |
<p>A DNA construct is provided comprising a first DNA encoding the gamma -interferon signal peptide linked to the 5' end of a second DNA encoding a human protein, e.g. a cytokine such as TNF, not naturally linked to said signal peptide, wherein said signal peptide has the property of augmenting the secretion of said human protein from a mammalian cell. Such a DNA construct may be a vector such as a retroviral vector. Also provided are virions carrying a DNA vector of the invention or a reverse transcript thereof.</p> |
申请公布号 |
EP0897987(A2) |
申请公布日期 |
1999.02.24 |
申请号 |
EP19980112614 |
申请日期 |
1990.10.23 |
申请人 |
CHIRON CORPORATION |
发明人 |
KRIEGLER, MICHAEL;PEREZ, CARL, F. |
分类号 |
C12N5/10;A01N63/00;A61K9/50;A61K35/76;A61K38/00;A61K38/19;A61K38/21;A61K38/22;A61K48/00;A61P35/00;C07K14/47;C07K14/525;C07K14/57;C12N5/08;C12N5/22;C12N7/00;C12N15/09;C12N15/19;C12N15/23;C12N15/28;C12N15/48;C12N15/867;C12P21/02;C12R1/91;C12R1/92;(IPC1-7):C12N15/86;C12N15/62;A61K47/00;C07K14/00 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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