摘要 |
Cascade polymer complexes that contain a) complexing ligands of general formula IA-{X-[Y-(Z-(W-Kw)z)y]x}a, (I) in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, that 16</=axxxyxzxw</=64 holds true for the product of the multiplicities, and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane reproduction unit, b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as d) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.
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申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
SCHMITT-WILLICH, HERIBERT;PLATZEK, JOHANNES;RADUCHEL, BERND;WEINMANN, HANNS-JOACHIM;EBERT, WOLFGANG;MISSELWITZ, BERND;MUHLER, ANDREAS;FRENZEL, THOMAS |