发明名称 Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
摘要 Cascade polymer complexes that contain a) complexing ligands of general formula IA-{X-[Y-(Z-(W-Kw)z)y]x}a, (I) in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, that 16</=axxxyxzxw</=64 holds true for the product of the multiplicities, and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane reproduction unit, b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as d) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.
申请公布号 US5874061(A) 申请公布日期 1999.02.23
申请号 US19960777666 申请日期 1996.12.20
申请人 SCHERING AKTIENGESELLSCHAFT 发明人 SCHMITT-WILLICH, HERIBERT;PLATZEK, JOHANNES;RADUCHEL, BERND;WEINMANN, HANNS-JOACHIM;EBERT, WOLFGANG;MISSELWITZ, BERND;MUHLER, ANDREAS;FRENZEL, THOMAS
分类号 A61K49/04;A61K49/08;(IPC1-7):A61B5/055;C07D225/00;C08F283/00;C07F5/00 主分类号 A61K49/04
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