| 摘要 |
PROBLEM TO BE SOLVED: To provide a material that can sustainedly release an anticoagulation activate substance from the surface of a base material and can be treated in detail. SOLUTION: The antithrombotic property is given to the surface of a medical instrument by treating the surface of a base material using an application liquid, a mixture of an anticoagulation active substance and a dispersion liquid of polymer particles. When a polymer particle dispersion liquid mixed with an anticoagulation active substance is applied to a base material, the polymer particles form a matrix on the base material, and a layer where the anticoagulation active substance is dispersed uniformly in the matrix, is formed. The anticoagulation active substance can give the superior antithrombotic property to the surface of a base material by being released gradually by diffusion in the matrix. |
