PRODUCTION OF LIPOSOME DISPERSION

摘要

PROBLEM TO BE SOLVED: To produce a liposome dispersion excellent in long-term stability in an industrial scale in the liposome dispersion using saturated phospholipid as membrane lipid. SOLUTION: In a liposome dispersion using saturated phospholipid as membrane lipid, a rough dispersion of liposome is ejected as a single jet stream and the jet stream is directionally converted by a counterposed bottom surface to be allowed to flow backward along a side wall so as to surround the jet stream to apply finely pulverizing treatment to the liposome rough dispersion by the shearing force generated at the interface of the jet stream and the back flow to obtain liposome with an average particle size of 70 nm or less and the max. particle size of 300 nm or less.