| 发明名称 |
N-linked sulfonamides of heterocyclic thioesters |
| 摘要 |
This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
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| 申请公布号 |
US5874449(A) |
申请公布日期 |
1999.02.23 |
| 申请号 |
US19960775584 |
申请日期 |
1996.12.31 |
| 申请人 |
GPI NIL HOLDINGS, INC. |
发明人 |
HAMILTON, GREGORY S.;LI, JIA-HE;HUANG, WEI |
| 分类号 |
A61K31/40;C07D207/48;C07D211/96;(IPC1-7):A61K31/40;A61K31/445 |
主分类号 |
A61K31/40 |
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