发明名称 |
Cyclic peptide antifungal agents |
摘要 |
The present invention provides phosphonylating agents and phosphonylation conditions that are compatible with the acid- and base-sensitive compounds and which promote a regioselective and reproducible conversion to a phosphonate compound. Also provided are intermediates that may be used to prepare phosphonate derivatives of cyclic peptides antifungal agent and a process for converting the phosphonates to the desired phosphonic acid prodrugs. |
申请公布号 |
AU8687798(A) |
申请公布日期 |
1999.02.22 |
申请号 |
AU19980086877 |
申请日期 |
1998.08.03 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
JUNIOR JOHN LEO GRUTSCH;MARVIN MARTIN HANSEN;ALLEN ROBERT HARKNESS;UKO EFFIONG UDODONG;DANIEL EDWARD VERRAL II |
分类号 |
A61K38/00;C07F9/40;C07H13/00;C07K7/56 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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