SUPERPOTENT CALCITONIN ANALOGS HAVING GREATLY INCREASED HYPOCALCEMIC ACTION IN VIVO

摘要

The invention relates to calcitonins and calcitonin derivatives such as are empl oyed for the therapy, for example, of osteoporosis, of Paget's disease or of hypercal cemia. The calcitonins and calcitonin derivatives according to the invention are distin guished by a bridging of the amino acids present in the positions 17 and 21. In this cas e, by means of suitable choice of the amino acids present in these positions an 18-membered or 19-membered ring is produced. This ring leads to an increased conformational stability and to an increased activity of the modified calcitonin . A particularly suitable hCt (human Ct) analog is the cyclo17,21-¢Asp17,Om21!-hCt according to the invention having a 19-membered ring structure between the lactam-bridged Asp17 and Om21.