PROCESS FOR SELECTIVE PREPARATION OF 7-[(7-(S)-AMINO-5- AZASPIRO [2,4]HEPTAN-5-YL) -8-CHLORO-6-FLUORO-1- [(IR,2S)-2-FLUOROCYCLOPROPYL)-4-OXO-1,4-DEHYDROAMINOLINE- 3-CARBOXYLIC ACID 3/2 HYDRATE, ANHYDROUS 7-[(7-(S)-AMINO- 5-AZASPIRO [2,4]HEPTAN-5-YL)-8-CHLORO-6-FLUORO-1-(1R,2S)- 2-FLUOROCYCLOPROPYL-4-OXO-1,4-DIHYDROQUINOLINE-3- CARBOXYLIC ACID AND PHARMACEUTICAL COMPOSITION HAVING ANTIBACTERIAL ACTIVITY

摘要

FIELD: pharmaceutical industry. SUBSTANCE: claimed process for preparing any of forms: anhydrous 7-[(7-(S)amino-5-azaspiro(2,4) heptan-5-yl)-8- chloro-6-fluoro-1-[(1R, 2S)-2-fluorocyclopropyl)-4-oxo- 1,4-dihydroquinoline-3-carboxylic acid 1/2 hydrate, 1 hydrate and 3/2 hydrate comprises treating compound in aqueous solvent or water, or recrystallizing compound from aqueous solvent or water. The present invention also describes said anhydrous acid based composition having antibacterial activity. Anhydrous acid also shows antimicrobial activity. EFFECT: improved properties of the pharmaceutical composition. 7 cl, 4 dwg, 7 ex, 1 tbl