发明名称 |
VITAMIN D ANALOGS, PROCESS FOR PREPARATION THEREOF, INTERMEDIATE COMPOSITION, AND METHOD FOR SUPPRESSING MORBID STATES |
摘要 |
FIELD: medicine. SUBSTANCE: present invention describes compounds of formula (I): <EMI ID=0.381 HE=60 WI=66 TI=CHI> wherein X is hydroxy; R and R are the same or different and are methyl, ethyl or trifluoromethyl; Q is singly bond or Q is (CH<SB>2</SB>)<SB>n</SB>, wherein n is 0.1-4, and m is 0 or 1. Compounds have antiinflammatory and immunomodulating activity and are capable of inducing differentiation and inhibition of undesired proliferation of some cells. The present invention also describes preparation process, intermediate compound for preparing compound of formula (I) and pharmaceutical composition having antiproliferating activity and method for suppressing morbid states characterized by pathologic cell differentiation and proliferation such as cancer and psoriasis using compounds of formula (I). EFFECT: improved properties of the pharmaceutical composition and more efficient suppression method. 12 cl, 6 dwg, 20 ex, 1 tbl
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申请公布号 |
RU2126384(C1) |
申请公布日期 |
1999.02.20 |
申请号 |
RU19920016313 |
申请日期 |
1991.07.11 |
申请人 |
LEO FARMAS'JUTIKAL PRODAKTS LTD. A/S |
发明人 |
KLAUS OGE SVENSGORD BRETTING |
分类号 |
A61K31/59;A61K31/593;A61P3/02;A61P3/08;A61P9/12;A61P17/00;A61P29/00;A61P35/00;A61P37/00;A61P37/04;A61P43/00;C07C401/00;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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