MENINGOCOCCUS VACCINE COMPRISING THE VALENCE OF BZ83 STRAIN

摘要

The invention concerns a pharmaceutical composition comprising (i) the subunit of least molecular weight (TbpB) of the human transferrin receptor (HTR) of a Neisseria meningitis strain having a DNA sequence coding for Tbp, (a) which contains two AvaII restriction sites, 3 HincII restriction sites, no VspI restriction site and no XhoI restriction site or (b) from which it is possible to generate by PCR (polymerase chain reaction) using primers P3 of formula 5'-AAGACCAAGGCGGATACGGTTTTGC-3' and P4 of formula 5'-GAAGACGAGTCGGAAACAAAGGGATG-3', a polynucleotide of 765 to 775 nucleotides. Such a strain is for example the BZ83 strain whereof the DNA sequence coding for TbpB is shown in the SEQ ID NO 1.