ANTIBODIES TO OXIDATION-SPECIFIC EPITOPES ON LIPOPROTEIN ANDMETHODS FOR THEIR USE IN DETECTING, MONITORING AND INHIBITING THE GROWTH OFATHEROMA

摘要

The invention relates to monoclonal antibodies which differentially bind oxidation-specific epitopes on lipoprotein in blood, arterial tissue and vascular tissue, including atherosclerotic plaque formed in arterial tissue and vascular tissue through lipoprotein oxidation. Methods for use of the antibodies in detecting and monitoring lipoprotein oxidation in vivo and in vitro are described, as are methods for inhibiting lipoprotein oxidation in vivo.