| 摘要 |
<p>A nucleic acid uptake and release vehicle comprising an adenovirus penton base protein; and an influenza virus hemmagglutinin endosomolytic peptide is disclosed, which optionally may also comprise a polylysylleucyl peptide so as to provide additional sites for nucleic acid attachment; as well as a nuclear localization signal peptide so as to enhance intranuclear localization of delivered nucleic acid. The vehicle can be utilized to enhance the intracellular delivery of nucleic acid molecules.</p> |
