摘要 |
<p>A mixture formed from an alkoxy-2-naphthaldehyde (e.g., 6-methoxy-2-naphthaldehyde), acetone, and aqueous NaOH and/or KOH is heated at 20 to 56 °C for 0.25 to 2 hours such that the conversion of monoalkoxy-substituted 2-naphthaldehyde is at least 97 % and the yield of (alkoxy-substituted 2-nalphthyl)-3-buten-2-one is at least 95 % based on the monoalkoxy-substituted 2-naphthaldehyde used in forming the mixture. The (alkoxy-substituted 2-naphthyl)-3-buten-2-one can be hydrogenated using, for example, a Pd/C catalyst to form the corresponding saturated ketone. The process enables efficient production of precursors of nabumetone and related pharmaceuticals by a clean, highly efficient reaction.</p> |