发明名称 |
SELF-EMULSIFYING FORMULATION FOR LIPOPHILIC COMPOUNDS |
摘要 |
The present invention provides a novel pharmaceutical composition based on the use of a particular oil phase which comprises a lipophilic, pharmaceutically active agent, a mixture of diglyceride and monoglyceride in a ratio of from about 9:1 to about 6:4 by weight (diglyceride:monoglyceride) wherein the diglyceride and monoglyceride are mono- or di-unsaturated fatty acid esters of glycerol having sixteen to twenty-two carbon chain length, one or more pharmaceutically acceptable solvents, and one or more pharmaceutically acceptable surfactants. The composition is in a form of self-emulsifying formulation which provides high concentration and high oral bioavailability for lipophilic compounds.
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申请公布号 |
WO9906024(A1) |
申请公布日期 |
1999.02.11 |
申请号 |
WO1998US14818 |
申请日期 |
1998.07.27 |
申请人 |
PHARMACIA & UPJOHN COMPANY;MOROZOWICH, WALTER;GAO, PING |
发明人 |
MOROZOWICH, WALTER;GAO, PING |
分类号 |
C07D405/12;A61J3/07;A61K9/107;A61K9/48;A61K31/192;A61K31/337;A61K31/355;A61K31/366;A61K31/4166;A61K31/4433;A61K31/4439;A61K31/4745;A61K31/496;A61K31/5575;A61K31/568;A61K31/57;A61K47/14;A61P31/14;A61P31/18;A61P37/04;(IPC1-7):A61K9/107 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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