发明名称 |
METHOD AND APPARATUS FOR USING ELECTROPORATION MEDIATED DELIVERY OF DRUGS AND GENES |
摘要 |
<p>This invention is a method, and apparatus (100) for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus (100) of the invention, and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage, and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode (114) having a "keying" element that determines the set point of the therapy voltage pulse, and/or selective array switching patterns. A number of electrode applicator designs permit access to, and treatment of a variety of tissue sites. Another embodiment provides a laparascopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.</p> |
申请公布号 |
CA2268026(A1) |
申请公布日期 |
1999.02.11 |
申请号 |
CA19982268026 |
申请日期 |
1998.07.31 |
申请人 |
GENETRONICS, INC. |
发明人 |
NANDA, GURVINDER S.;HOFMANN, GUNTER A.;DEV, SUKHENDU B.;DIMMER, STEVEN C.;LEVATTER, JEFFREY I. |
分类号 |
A61B17/34;A61B18/14;A61N1/00;A61N1/04;A61N1/05;A61N1/30;A61N1/32;(IPC1-7):A61N1/04 |
主分类号 |
A61B17/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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