摘要 |
The invention relates to new tricyclic 2,3-benzodiazepine derivatives of general formula (I), stereoisomers and acid addition salts thereof and to pharmaceutical compositions containing the same, wherein the main substituent meanings are as follows: R<1> and R<2> represent independently hydrogen, halogen, a C1-4 alkyl, C1-4 alkoxy, nitro, trifluoromethyl or optionally substituted amino group, X represents hydrogen or chlorine atom, Y represents chlorine or bromine atom, A represents a 5-membered heterocyclic group containing 1 to 3 nitrogen atoms. The compounds are suitable for treating conditions associated with muscle spasms, epilepsy as well as acute and chronic forms of neurodegenerative diseases.
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申请人 |
GYOGYSZERKUTATO INTEZET KFT.;ABRAHAM, GIZELLA;CSUZDI, EMESE;SOLYOM, SANDOR;BERZSENYI, PAL;TARNAWA, ISTVAN;ANDRASI, FERENC;LING, ISTVAN;HAMORI, TAMAS;HORVATH, KATALIN;MORAVCSIK, IMRE;PALLAGI, ISTVAN;SIMAY, ANTAL |
发明人 |
ABRAHAM, GIZELLA;CSUZDI, EMESE;SOLYOM, SANDOR;BERZSENYI, PAL;TARNAWA, ISTVAN;ANDRASI, FERENC;LING, ISTVAN;HAMORI, TAMAS;HORVATH, KATALIN;MORAVCSIK, IMRE;PALLAGI, ISTVAN;SIMAY, ANTAL |