METHOD FOR THE PRODUCTION OF TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTRATING BUPRENORPHINE ONTO THE SKIN

摘要

A reservoir layer is prepared by homogenising mixture which contains 20 - 50 percent by weight of physiologically acceptable polymeric material, 0.1 - 30 percent by weight of plasticiser paying heed to selected polymeric material, 0.1 - 20 percent of buprenorphine base or its pharmaceutically acceptable salts and 0.1 - 30 percent by weight of solvent for the active substance base with at least one acid group added with a highly volatile solvent of buprenorphine base and is applied upon a backing layer or protective layer, subsequently the highly volatile solvent is removed.