DNA FRAGMENTS, PLASMIDS AND MICROORGANISMS CONTAINING DNA FRAGMENTS AND BIOTECHNOLOGICAL METHOD OF BIOTIN PRODUCTION

摘要

DNA fragments and plasmids comprise the bioB, bioF, bioC, bioD and bioA genes responsible for biosynthesis of biotin, or their functionally equivalent genetic variants and mutants from enteric bacteria, wherein the genes are arranged in a transcription unit. The invention also describes microorganisms containing these DNA fragments and plasmids and a method of producing biotin using these microorganisms.