ARYL-SUBSTITUTED PYRAZOLOQUINOLINONE DERIVATIVES AS GABA ALPHA 5 RECEPTOR INVERSE AGONISTS

摘要

8-Bromo-2-(4-methoxyphenyl) -2,5-dihydro-pyrazolo [4,3-c]quinolin-3-one; and 8-bromo-2-phenyl -2,5-dihydro-pyrazolo [4,3-c]quinolin-3-one are disclosed. The compounds are inverse agonists at GABA alpha 5 receptors, and are useful in enhancing cognition, particularly in subjects suffering from Alzheimer's Disease.