ORTHO-SUBSTITUTED DERIVATIVES OF BENZOIC ACID, METHOD OF THEIR SYNTHESIS, METHOD OF PREPARING PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to ortho-substituted derivatives of benzoic acid of the formula (I) where R - alkyl, halogen or XR ; R is SOn-R or -SO2NR4R ; R is CN or halogen; Q is -N=C(NH2)2, OA or OH; R4,R are H or C1-6-alkyl; R is C1-6-alkyl; X is O or NR and n = 2, and their physiologically compatible salts and a pharmaceutical composition based on compounds said shows cardioprotective effect. Compounds can be used for drugs preparing or as intermediate compounds for synthesis of other active substances. EFFECT: improved method of synthesis. 7 cl, 1 tbl, 20 ex