| 摘要 |
Polyunsaturated 24a,24b-dihomo-9,10-secocholestane derivatives of formula wherein A is a single or double bond, B1 and B2 are each independently CH=CH or C 3BOND C, T is CH2 or CH2CH2, X is -CH2- or >C=CH2, R1 is H, F or OH, R2 and R3 are each independently lower alkyl or CF3, or C(R2,R3) is C3-6-cycloalkyl, are useful in the treatment or prevention of vitamin D dependent disorders and of IL-12-dependent autoimmune diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis, leukemia, osteoporosis, hyperparathyroidism accompanying renal failure, multiple sclerosis, transplant rejection, graft vs. host disease, rheumatoid arthritis, insulin-dependent diabetes mellitus, inflammatory bowel disease, septic shock and allergic encephalomyelitis. |
