| 摘要 |
FIELD: organic chemistry. SUBSTANCE: invention relates to 6,7-modified paclitaxels of the formula (I) <EMI ID=0.291 HE=39 WI=78 TI=CHI> where R is R where R means RO or R; R - radical of the formula W-R where W - a bond, C<SB>2-6</SB>-alkenediyl or -(CH<SB>2</SB>)<SB>t</SB>; t = 1-6; R - phenyl, furyl, thienyl or oxazolyl; R means -OCOR, -OR, OSO<SB>2</SB>R, -OCOO-(CH<SB>2</SB>)<SB>t</SB>R or -OCOOR; R and R taken together form a bond with carbon atoms to which they are bound; R and R - alkyl, alkenyl, C<SB>3-6</SB>-cycloalkyl or phenyl possibly substituted with 1-3 alkyls or halogen atoms. Compounds of the formula (I) show antitumor activity. EFFECT: improved method of synthesis, enhanced antitumor activity. 7 cl, 6 dwg, 1 tbl, 26 ex
|
