发明名称 |
Process for isolation of 1-[N2-((S-Ethoxycarbonyl)-3-phenylpropyl)-N6-trifluoroacetyl]-L-lysyl-L-proline (Lisinopril (Tfa) ethylester, LPE) |
摘要 |
Isolation of 1-ÄN<2>-((S)-ethoxycarbonyl)-3-phenylpropyl)-N<6>-trifluoroacetylÜ-L- lysyl-L-proline (I) (i.e. lisinoprilÄTFAÜ ethyl ester) from an aqueous solution obtained in the production of (I), comprises extraction followed by crystallisation. The novelty is that the solvent (or solvent mixture) used for extraction of (I) is also a major component of the solvent (mixture) used for crystallisation of (I). Also claimed is (I) which exhibits reflections at 6.7241, 9.4851, 11.9034, 16.3074 and 17.8722 (2&thetas; ). |
申请公布号 |
EP0896000(A1) |
申请公布日期 |
1999.02.10 |
申请号 |
EP19980113455 |
申请日期 |
1998.07.18 |
申请人 |
DEGUSSA-HUELS AKTIENGESELLSCHAFT |
发明人 |
KOTTENHAHN, MATTHIAS, DR.;MOELLER, ROLAND;KRAFT, MICHAEL;DRAUZ, KARLHEINZ, PROF. DR.;STINGL, KLAUS, DR. |
分类号 |
C07K1/30;A61K38/00;C07K5/02;C07K5/068 |
主分类号 |
C07K1/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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