Hexadecasaccharide-protein conjugate vaccine for (shigella dysenteriae) type

摘要

The present invention pertains to isolated natural, modified natural or synthetic oligo- or polysaccharides which have [3)- alpha -L-Rhap-(1}2)- alpha -D-Galp-(1}3)- alpha -D-GlcpNAc-(1}3)- alpha -L-Rhap-(1}]n subunits and which are structurally related to and/or antigenically similar to an antigenic determinant of the O-specific polysaccharide of Shigella dysenteriae type 1. The oligo- or polysaccharides may be conjugated to a carrier to form conjugates. These oligo- or polysaccharides and conjugates thereof are immunogenic and elicit serum antibodies that are bactericidal or bacteriostatic against Shigella dysenteriae, in particular Shigella dysenteriae type 1, and are useful in the prevention and treatment of shigellosis. These oligo- or polysaccharides and conjugates thereof, and the antibodies which they elicit, are also useful for diagnosing shigellosis caused by Shigella dysentariae type 1.