| 摘要 |
Novel soluble, secreted tumor necrosis factor receptor (TNRF) polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise four cysteine-rich repeats that are homologous to other tumor necrosis factor receptors, in particular the soluble, secreted tumor necrosis factor receptor osteoprotegerin. The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that promote cellular maturation and bone cell regulation. |
