| 摘要 |
FIELD: organic synthesis. SUBSTANCE: invention provides new carboxamides with general formula I: <EMI ID=0.279 HE=27 WI=33 TI=CHI> (I) wherein E is hydrogen; G hydrogen, lower alkyl, lower alkylenecarboxy, lower alkoxycarbonyl, lower alkanoyl, lower alkanoyloxy, lower alkoxy, aryl- lower alkoxy, carboxamide group, etc.; M is hydrogen, lower alkyl, lower alkenyl, aryl, heteroaryl, or cycloalkyl; L hydrogen, lower alkyl, aryl, or cycloalkyl; or M and L together with atoms adjacent to them represent heterocyclic nitrogen atom; or E and G together form methylene or carbonyl group; A is hydrogen, alkyl, or arylalkyl; Q is group of formula <EMI ID=0.280 HE=21 WI=27 TI=CHI> or <EMI ID=0.281 HE=21 WI=24 TI=CHI> wherein T is methylene or oxygen, and R and R are hydrogen, lower alkoxycarbonyl, or hydroxyl. EFFECT: new means to inhibit thrombin-induced accumulation of platelets and coagulation of fibrinogen in blood serum. 18 cl, 1 tbl, 53 ex
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