IMIDAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of imidazole of the formula (I) where Y is H, phenyl, phenylalkyl, pyridyl, pyridylalkyl; Ar and Ar are phenylene; X and X are O, S, SO or SO2; R is H or alkyl; R and R are methylene, ethylene or propylene. Synthesized compounds show capacity to inhibit enzyme lipoxygenase. Compounds of the formula (I) can be used for treatment of patients with bronchial asthma, skin diseases and arthritis in mammals. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 9 cl, 51 ex