| 摘要 |
The invention concerns pyrazine derivatives of formula (1) in which a pharmaceutical composition comprising at least one compound of formula:in whichR represents a nitrogen atom, R1 and R3 each represent the same radical selected from the group consisting of -CO-NR5R6, -CO-N(CH(CH2OH)2)2, -CO-N(CH2OH)2, -CO-N(CH2-CH(CH2OH)2)2, -CO-N(CH2-(CHOH)n-CH2OH)2 in which n is equal to 0, 1, 2, 3 or 4, -CH2-O-R6, -NR5-CO-R6, -CH2-NR5R6, -CH2-N(CH2OH)2, -CH2-N(CH2-(CHOH)y-CH2OH)2 in which y is equal to 0, 1, 2, 3 or 4, -CH2-N(CH(CH2OH)2)2 and -CH2-N(CH2-CH(CH2OH)2)2 and R2 and R4 each represents a hydrogen atom,R5 represents a hydrogen atom or an alkyl radical,R6 represents a radical -CH2-(CHOH)m-CH2OH in which m is equal to 0, 1, 2, 3 or 4, -alk-O-alk-CH2OH, -alk-O-alk, -CH(CH2OH)2, -C(CH2OH)3, -C(CH3) (CH2OH)2, -CH2-CH(CH2OH)2 or -CH(CH2OH)-(CHOH)x-CH2OH in which x is equal to 1, 2, 3 or 4, alk represents an alkyl radical, the alkyl radicals containing, unless otherwise stated, 1 to 6 carbon atoms in a straight or branched chain, stereoisomers thereof and salts thereof with an inorganic or organic acid and their preparation. |
