发明名称 |
9-(2-phosphonylmethoxyethyl) guanine |
摘要 |
This invention relates to new nucleotide analogues and solves the technical problem of their use as biologically active compounds. The subject of this invention are N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases, easily accessible from heterocyolic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds, according to this invention, exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.
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申请公布号 |
US5869467(A) |
申请公布日期 |
1999.02.09 |
申请号 |
US19950412398 |
申请日期 |
1995.03.28 |
申请人 |
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC;REGA STICHTING V.Z.W. |
发明人 |
HOLY, ANTONIN;ROSENBERG, IVAN;DE CLERCQ, ERIK D. A. |
分类号 |
A61K31/66;A61K31/675;A61P31/12;C07F9/6512;C07F9/6561;(IPC1-7):A61K31/675;C07F9/651 |
主分类号 |
A61K31/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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