Terpenoidic derivatives useful as antitumor agents

摘要

PCT No. PCT/EP96/01688 Sec. 371 Date Jan. 15, 1997 Sec. 102(e) Date Jan. 15, 1997 PCT Filed Apr. 23, 1996 PCT Pub. No. WO96/36335 PCT Pub. Date Nov. 21, 1996A method of treating tumors in a human or animal by administering thereto a pharmaceutically effective amount of a Sarcodictyin compound selected from Sarcodictyin A, B, C, D, E, and F. Sarcodictyin A has the formula (-)-(4R,4aR,7R,10S,11S,12aR,1Z,5E,8Z)-7,10-Epoxy3,4,4a,7,10,11,12,12a-octahydro-7-hydroxy-6-(methoxy-carbonyl)-1,10- dimethyl-4-(1-methylethyl)benzo cyclodecen-11-yl(E)-3-(1-Methyl-1H-imidazol-4-yl) acrylate (Sarcodictyin A).