Process and a novel intermediate for the preparation of flecainide

摘要

The invention relates to processes for the preparation of compounds of the formulawherein R is a 2-piperidyl or 2-pyridyl radical, and pharmaceutically acceptable salts thereof, the process comprising the steps of:a) reacting 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid or a salt thereof with a haloacetonitrile to form a cyanomethyl ester of formulab) reacting the ester with an amine of the formula RCH2NH2, where R is as defined above.