| 摘要 |
<p>The present invention relates to the use of 'protein painting' (the addition of exogenous, lipid-modified proteins) to improve embryonic viability, development, and implantation. It is shown here that a lipid-modified protein, e.g., GPI-modified exogenous Qa-2 protein, spontaneously incorporates into the plasma membrane of B6.K1 T cells and onto Ped slow preimplantation embryos. It is also shown that, given enough time after incorporation, the exogenous Qa-2 protein increases the rate of development of early embryos cultured in vitro, most likely by diffusing in the plasma membrane until it is 'connected' to its functional signaling machinery. Protein painting of embryos has the potential, therefore, to be a valuable tool in enhancing embryo development and implantation.</p> |
